Milen Panayotov studied composition at the National Academy of Music in Sofia, Bulgaria under Prof. Dimitar Tapkov. He later perfected his skills in composition under the guidance of such outstanding composers as Mark Kopytman at the Brandenburgisches Colloquium für Neue Musik, Peter-Michael Hamel and Alejandro Iglesias-Rossi in Poland, and György Kurtág and Julio Estrada at the Darmstädter Ferienkurse für Neue Musik. He also specialized in composition with Prof. Mark Kopytman at the Jerusalem Academy of Music and Dance.
Three of his works (Da re diesis al mi bemolle, for two pianos, 1996; No Keys!, for piano, 2003; and Musica per archi senza percussione e celesta, 2007) have been represented at the International Rostrum of Composers under the aegis of UNESCO. The latter work was commissioned and premiered by the Sofia Soloists Chamber Ensemble conducted by Plamen Djouroff.
In April 2008 Catalan composer pianist and improviser Josep-Maria Balanyà and Milen Panayotov performed on the stalactites and stalagmites in the "Sâeva Dupka" cave in North West Bulgaria.